Research Article

Human Immunodeficiency Virus and Hepatitis B Virus Co-infection Studies among Patients attending Selected Hospitals in Gusau, Zamfara State, Nigeria

Habibu, A1*, Muhammad U-K2, Baki A. S2, Gambo S.3
1 Department of Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria
2 Department of Microbiology, Usmanu Nigeria Danfodiyo University, Sokoto,
3 Department of Microbiology Federal University Gusau, Nigeria
* Corresponding author: ahabibu01@gmail.com
Published: Jun, 2021
DOI: 10.67614/njm.2021.05h79j9n
Pages: 5454-5459

Abstract

Human Immunodeficiency virus (HIV) and Hepatitis B virus are among the leading causes of fatal infections worldwide. This study was conducted between August-December 2018 to determine the sero-prevalence of HIV/HBV co-infection among patients attending two selected Hospitals in Gusau, Nigeria. One hundred and sixty eight (168) study subjects were recruited for this study. Blood samples were collected by venepuncture and screened for the presence of HIV antibodies and Hepatitis B surface antigen (HbsAg) using determine and Hepatitis B first response rapid detection kits respectively. The HIV positive blood samples were retested using uni-gold and analyzed for CD4+ count. HbsAg positive blood samples were confirmed by ELISA and retested for various markers of HBV. Antibodies against HIV were detected in 8.3% (14/168) while HbsAg in 7.7% (13/168) and a coinfection of 2.9% (5/168). The mean CD4+ count in HIV positive subject was 354.4cells/µl of blood. Test for markers of HBV indicate Anti HBc as the most predominant (46.1%) while Anti-HBs was the least predominant. Both HIV and HBV were significantly associated with family type and history of sexually STDs. The findings of this study suggest that thorough investigations be employed especially for blood donors so that adequate clinical management can be planned for the infected persons as soon as they are diagnosed

Keywords

Prevalence HIV HBV and Coinfections.

References

  1. Aba, H.O. (2013) Co-infection of HIV and HBV among Pregnant women attending antenatal care in some Hospitals in Kaduna Metropolis, Nigeria. Journal of Infectious Disesase 340:114.118
  2. Adewole, O.O., Anteyi, E., Ajuwon, Z., Wada, I., Elegba, F., Ahmed, P., Betiku, Y., Okpe, A., Eze, S., Ogboche, T. and Erhabor, G.E. (2009). Hepatitis B and C virus co-infection in Nigerian patients with HIV infection. Journal of Infectious Diseases in Developing Countries, 3:369-375.
  3. Aghasadeghi, M.R., Bahramali, G., Sadat, S.M., Farahani, A., Mohraz, M., Davar Siadat, S.,Mostafavi, E., Memarnejadian, A., Ardestani, M.S., Vahabpour, R., Saraji, A.A. and Delbaz, S.A. (2011). Variants in HBV monoinfected and HBV/HIV co-infected Iranian patients under lamivudine treatment. Journal of Curren Human Immunodeficiency Virus, 9:263-269.
  4. Aliyu, B.S., Manga, S.B. and Isa M.A. (2013). Prevalence of hepatitis B virus among HIV positive patients attending specialist hospital Sokoto. International Journal of Environment, 2:2091-2854.
  5. Azhani, M. and Stephane, T. (2017). Prevalence of Human Immunodeficiency Virus Hepatitis B Virus co-infection among adult Nigerians in Mahalapye, Ngami, Serowe Botswana: a descriptive cross sectional study. South African Family Practice 1:1-4.
  6. Buseri, F.I., Seiyaboh, E. and Jeremiah, Z.A. (2010). Surveying infections among pregnant women in the Niger Delta, Nigeria. Journal of Global Infectious Diseases, 2:203-211
  7. Federal Ministry of Health (Nigeria 2010b). National training course on early infant diagnosis of HIV infection: Trainers guide: 4-6
  8. Hoffman j, Van j, Colebunders R. and Mckellar M. (2010). Role of CD4 count in HIV management. Journal of HIV Therapy, 4:27-39.
  9. Kanu, A.M., Ihekwevwem, E., Kalu, S.E. and Nwanko, G.N. (2015). Prevalence of hepatitis B and HIV co-infection among blood donors in Abia state university teaching hospital, Aba, South East, Nigeria. International Journal of Curreni Microbiology and Applied Sciences, 4:762-768
  10. Lacombe K., Bottero J, Lemoine M., Boyd A. and P. M. Girard (2010). HIV/hepatitis B virus co-infection: current challenges and new strategies. Journal of Antimicrobial Chemotherapy, 65: 10-17.
  11. Liu, Z., Hou J. (2006). Hepatitis B and Hepatitis C virus dual infection. International Journal of Medical Sciences, 21:57-62.
  12. Oladele, O., Adesina, D., Omotola, T. and Sunday, T. (2013). Prevalence of HBsAg and HIV among blood donors in Oshogbo, Osun State, Nigeria. International Journal of Medicine and Medical Sciences.3:68-71.
  13. Olokoba, A.B., Salawu, F.K., Danburam, A., Olokoba, L.B., Midala, J.K., Badung, L.H., and Olatinwo, A. (2011). Hepatitis B and HIV co-infection in Native Africans with HIV infection in North-Western Nigeria- A calls for action. Nigerian Journal of Clinical Practise, 14:10-3.
  14. Omonkhelin, J. and Owolabi, E.A. (2010) .A review of viral infections in HIV positive patients using UBTH as a case study. African Journal of Health Sciences, 17:3-4
  15. Ortblad, K.F, Lozano, R. and Murray, C.J (2013). The burden of HIV: insights from the GBD 2010. AIDS, 27: 2003-2017.
  16. Richmann, D.D., Morgolis, D.M, Dekeney, M., Green, W.C., Hazuda, D. and Pomeraatz, R.G. (2009). The challenges of finding cure for HIV infection. Science, 323:1304-1307.
  17. Sadoh, A.E., Sadoh, W.E. and Iduoriyekemwen, N.J. (2011). HIV co-infection with Hepatitis B and C viruses among Nigerian children in anti-retroviral treatment program. South African Journal of Child Health 5:11-12.
  18. WHO Guidance on Antiretrovirals in HIV Prophylaxiss. (2012). Pharmaco Economic and Outcome News 69:2-5
How to Cite

A, H., U-K, M., S, B. A., & S., G. (2021). Human Immunodeficiency Virus and Hepatitis B Virus Co-infection Studies among Patients attending Selected Hospitals in Gusau, Zamfara State, Nigeria. Nigerian Journal of Microbiology, 35(1), 5454-5459. https://doi.org/10.67614/njm.2021.05h79j9n

H. A, M. U-K, B. A. S, and G. S., "Human Immunodeficiency Virus and Hepatitis B Virus Co-infection Studies among Patients attending Selected Hospitals in Gusau, Zamfara State, Nigeria," Nigerian Journal of Microbiology, vol. 35, no. 1, pp. 5454-5459, June 2021. doi: 10.67614/njm.2021.05h79j9n

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