Abstract

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Prevalence of impaired renal function among prostate enlarged adult attending General Hospitals in Benue State, Nigeria was carried out. Three hundred and sixty eight (368) samples of blood was collected from the 23 General Hospitals located in the Local Government Headquarters in Benue State, Nigeria. The plasma were used for the quantitative determination of prostate specific antigen (PSA), creatinine was quantitatively determined using MN CHIP 4 fully automated dry chemistry analyzer and Glomerular filtration rate (eGFR) was calculated using glomerular Filtration rate calculator software. The age of the patients were obtained from the case folders. The overall impaired renal function rate was 31.8 %. Patients within the ages 90-99 years had the highest impaired renal function (eGFR) of 80.0% and the least been those within the ages 40- 49 years with impaired renal function of (10.0%) The prevalence of impaired renal function with age groups was statistically significant (ꭓ2 = 51.50, p < 0.05). Those patients with prostate specific antigen (PSA) level of > 100 ng/mL had the highest rate of renal impairment of (67.6%) and the least been those with prostate specific antigen (PSA) of 0-19 ng/ml that had impaired renal function rate of 15.9%. Prevalence of impaired renal function with prostate specific antigen (PSA) was statistically significant (ꭓ2 = 31.04, p < 0.05).

Keywords: Prostate specific antigen (PSA), impaired renal function (eGFR), creatinine, MN CHIP 4.