Abstract

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Antimold resistance is common due to drug abuse, mutation caused by genetic recombination and others. In a bid to contribute new antimold agents to the pharmaceutical and medical world molds were isolated from selected areas on the campus of the University of Ilorin. Their sensitivity profiles were evaluated against commercial antimold drugs, synthesized metal complexes and the seed oil of Jatropha curcas. The isolates were cultured and antibiotic sensitivity test was carried out on the isolates using the disc-diffusion and agar-well diffusion methods. Most of the molds showed susceptibility to the azoles (clotrimazole, fluconazole and ketoconazole) with inhibition zones ranging from 12mm to 25mm. Geotrichum candidum showed resistance to fluconazole. Griseofulvin had the least activity with inhibition zone as low as 0mm. Fungusol had intermediate susceptibility with inhibition zone between 5mm to 21mm. Only Mucor circinelloides was resistant to the commercial antibiotics. The [Ca(HBAB)](NO3)2.2H2O complex, HBAB Schiffbase, and [Mg(HBAB)](NO3)2.4H2O complex synthesizedshowed minute level of antimicrobial activity against Aspergillus terreus, Geotrichum candidum and Trichosporon mucoides(2mm - 6mm). All the molds were resistant to Jatropha seed oil. In conclusion, the synthesized compounds if improved upon show promise of being good antimold agents.

Keywords: Sensitivity, Antimold, Synthesized metal complex, Disc, Agar-well, Jatropha.