Abstract

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Extracts of Nicotiana tabacum were investigated for phytochemical constituents and antifungal activities against certain dermatophytes: Epidermophyton floccosum , Microsporum canis and Trichophyton rubrum . The alcohol extract was made using 95% ethanol and 95% methanol as extracting solvent in the ratio of 2:1. The hot water extract was made by boiling sample in distilled water. The phytochemical analysis revealed the presence of carbohydrates, glycosides, fats and oil, saponin, and tannins. Alkaloids were in appreciable quantities while cyanogenicglycosides were absent. The crude extracts were acidic and exhibited antifungal activity against all the test organisms. The minimum inhibitory concentrations of the extracts on the organisms varied between 7.8 and 62.5mg/ml. The treatments were significantly different at p=0. 05. The mode of action of the extracts varied with the test organisms. This study revealed antifungal effect of leaf extract of Nicotiana tabacum on Epidermophyton floccosum , Microsporum canis and Trichophyton rubrum

Keywords: floccosum , Microsporum canis and Trichophyton rubrum