Abstract

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The infection process when C albicans grew in the filamentous and colonial forms were assessed in rats by determination of survival times, fungal burden from kidney and histological examination. Rats in the various immunological state survived C albicans in the Colonial form than in the filamentous form. Neutrophil deficient rats and rats depleted of all forms of immunity had the highest mortality with lowest mean survival times of 0.6±0.4 and 0.8 ±0.41 days respectively after infection with filamentous C albicans. There were no significant variations in the fungal kidney burden among the groups except for the Neutrophil deficient rats infected with filamentous C albicans that showed the lowest kidney burden 6.61 ± 0.73 cfu/g of kidney. Result indicates that there was variation in the relative invasion of the kidney by the C albicans when the organism grows in different morphological forms The result also mirrors the superiority of the immune status over morphological state of the organism and the consequences of certain regimen used in the treatment of candidiasis as shown on the effect of CPM, as this compound is an active substance in anti fungal drugs used in the treatment of infections caused by Candida albicans

Keywords: Mortality, Candidiasis, Anti fungal, Immunological, Filamentous, morphological