Abstract

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Antibiotic resistant bacteria (ARB) may be transmitted from livestock to humans through the oral-faecal route. Pseudomonas aeruginosa has been reported to have intrinsic resistance to many antibiotics combined with its ability to easily acquire antibiotic resistance determinants, which poses a significant threat to public health. This study investigated the presence of Pseudomonas aeruginosa, and also determined the antibiotic resistance profiles of the strains to other classes of antibiotics, in a cattle farm in Epe, Lagos State, Nigeria. Sixteen P. aeruginosa strains were isolated after the standard microbiological methods and biochemical testing. The strains were subjected to antimicrobial susceptibility testing, through the disc diffusion method against seven antimicrobial agents, and the minimum inhibitory concentration (MIC) for carbapenem (imipenem) antibiotics. Resistance was found in all antibiotics tested. The highest resistance values were observed for imipenem (68.75%), chloramphenicol (37.50%) and gentamicin (31.25%). The P. aeruginosa isolates also exhibited resistance to ciprofloxacin (12.50%), amoxicillin (12.50%), streptomycin (12.50%), and sparfloxacin (6.25%). The MIC values ranged between 8.0 and 32 µg of imipenem, with a resistance prevalence of 68.75% of the isolates. The findings highlight the significance of awareness and proactive actions in agricultural settings to protect public health and maintain the efficacy of current antibiotics. Also, there is an urgent need for increased surveillance and effective control methods to limit the spread of antibiotic-resistant bacteria.

Keywords: Antibiotics, multidrug resistance, Cattle farm; Pseudomonas aeruginosa