Research Article

ASSESSMENT OF PATHOGENIC POTENTIALS OF COLONIAL AND FILAMENTOUS Candida ALBICANS'IN VARIED IMMUNOLOGICAL STATE OF ANIMALS

Uzoechi A. U1*, Orji Justina C2, tNwachiikwn M.I.,2, Ohttocha P./Nzvachukwu I.O3
1 Department of Microbiology, Imo State University Owerri Imo State
2 Department of Microbiology, Federal University of Technology Owerri
3 Department of Microbiology, lino State University Owerri Imo State
* Corresponding author: uche4realab@yahoo.com
Published: Dec, 2015
DOI: 10.67614/njm.2015.ixbym78b
Pages: 3127-3138

Abstract

The infection process when C albicans grew in the filamentous and colonial forms were assessed in rats by determination of survival times, fungal burden from kidney and histological examination. Rats in the various immunological state survived C albicans in the Colonial form than in the filamentous form. Neutrophil deficient rats and rats depleted of all forms of immunity had the highest mortality with lowest mean survival times of 0.6±0.4 and 0.8 ±0.41 days respectively after infection with filamentous C albicans. There were no significant variations in the fungal kidney burden among the groups except for the Neutrophil deficient rats infected with filamentous C albicans that showed the lowest kidney burden 6.61 ± 0.73 cfu/g of kidney. Result indicates that there was variation in the relative invasion of the kidney by the C albicans when the organism grows in different morphological forms The result also mirrors the superiority of the immune status over morphological state of the organism and the consequences of certain regimen used in the treatment of candidiasis as shown on the effect of CPM, as this compound is an active substance in anti fungal drugs used in the treatment of infections caused by Candida albicans

Keywords

Mortality Candidiasis Anti fungal Immunological Filamentous morphological

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How to Cite

U, U. A., C, O. J., M.I.,, T., & I.O, O. P. (2015). ASSESSMENT OF PATHOGENIC POTENTIALS OF COLONIAL AND FILAMENTOUS Candida ALBICANS'IN VARIED IMMUNOLOGICAL STATE OF ANIMALS. Nigerian Journal of Microbiology, 29(2), 3127-3138. https://doi.org/10.67614/njm.2015.ixbym78b

U. A. U, O. J. C, T. M.I.,, and O. P. I.O, "ASSESSMENT OF PATHOGENIC POTENTIALS OF COLONIAL AND FILAMENTOUS Candida ALBICANS'IN VARIED IMMUNOLOGICAL STATE OF ANIMALS," Nigerian Journal of Microbiology, vol. 29, no. 2, pp. 3127-3138, December 2015. doi: 10.67614/njm.2015.ixbym78b

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